Takishi was a prisoner from Orochimaru's Northern Hideout. He and other prisoners were experimented upon with cursed seals.
After Orochimaru's death, Takishi and his fellow prisoners revolted, escaped their cells and killer their jailers. Takishi was eventually severely wounded. When he learned from Suigetsu that Team Snake was seeking to free Juugo, he mocked their ability to control the killer. His assurance that Juugo would kill them angered Suigetsu to the point of killing Takishi, even though Sasuke had ordered Suigetsu not to do so.