In the Batman: The Brave and the Bold episode "The Super-Batman of Planet X!". The respective fictional universes of Batman and Superman are merged, to create a unique setting based on France Herron's 1958 story in Batman #113. Vilsi Vaylar, a reporter for the Solar Cycle Globe from the planet Zur-En-Arrh, is an amalgam of Lois Lane and Vicki Vale. Vilsi Vaylar was played by DC Animated Universe voice actor, Dana Delany.
Lois Lane appears in "Battle of the Superheroes!", voiced by Sirena Irwin. In the episode, Lois is first seen being captured by Lex Luthor, only to be saved by Batman. When Lois unknowingly receives a Red Kryptonite necklace, it causes Superman to turn evil. Batman visits her and analyzing her necklace, and discover that it was Red Kryptonite. Lois and Jimmy Olsen were rescued by Krypto, when Superman attacked their protest march. Batman and Krypto had to fight Superman, until the effects of the Red Kryptonite wore off. Lois and Jimmy were present, when Batman and Superman found the real Luthor, since the one that was arrested before was one of Luthor's robotic duplicates. After Luthor was defeated, Superman apologize to both Lois and Jimmy for his behaviour, Lois tell Superman he can make up to her with dinner. Lois remarks that after all the trouble she and Jimmy go through, Clark end up writing the story revealing Luthor's part, in what Superman did, under the Red Kryptonite's control.