John Fitzgerald "Jack" Kennedy (May 29, 1917 – November 22, 1963), often referred to by his initials JFK, was the 35th President of the United States, serving from 1961 until his assassination in 1963.
John F. Kennedy appears at Jesus' birthday party in "The Most Adequate Christmas Ever".
Stan jokes that the studio they use in "Phantom of the Telethon" was where they faked the JFK assassination, before correcting it to having planned the JFK assassination.
A 'humorous' strike video at Langley Lanes in "Next of Pin" makes light of John F. Kennedy's assassination.
Stan takes over the CIA sound stage where he tells Steve that it was used in JFK's assassination in "Fight and Flight".