The Fatal Five made their first television appearance in the Justice League Unlimited episode "Far From Home".
The Fatal Five, consisting of the original five members (although both Emerald Empress and Tharok act as leaders), is one of the main villain teams on the Legion of Super Heroes animated series. The group appears in four episodes in season one. It is unclear when and how the group assembled in this continuity; the Sun-Eater storyline is adapted into the first-season finale, but the Fatal Five are the villains fought in the series premiere. The Fatal Five were released by Imperiex alongside the Legion of Super-Villains from their prison, though the group disbanded when Validus was taken by Imperiex, while the Emerald Empress was rendered powerless by Matter-Eater Lad and abandoned by her remaining teammates. Both Validus and Persuader were later seen operating alone, albeit under the aegis of Imperiex.
The Fatal Five appear in the 2019 DC Universe Original Movie Justice League vs. the Fatal Five. The team's line-up includes Emerald Empress, Tharok, Mano, Persuader, and Validus.[4][5] Tharok, Mano, and Persuader travel to the present to target Jessica Cruz so that she can take them to Oa where they can free Emerald Empress and Validus. During the fight against the Justice League and Star Boy, the Fatal Five are buried when the building they're in collapses on them.