Uzumaki Clan

The Uzumaki Clan was so feared for its sealing abilities that several villages ended up banding together to destroy their homeland. Its members include Mito, the first host of the Nine-Tailed Fox (and the 1st Hokage's wife), Kushina, the second host of the Fox, Pain/Nagato, who single-handedly demolishes the Hidden Leaf Village, Karin, an unparalleled chakra detector with healing abilities, and Naruto, the series's protagonist. And that's not even including, by virtue of being Kushina's husband and Naruto's father, the Fourth Hokage, who was so feared that Hidden Stone shinobi were ordered to run away upon seeing him.