Angelica Charlotte Pickles is the main antagonist and secondary tritagonist of the series. While this is so, she acts more as an antihero in the films and often sides with the babies at the end against the films' respective main villains. She is voiced by Cheryl Chase in both Rugrats (the original and revival) and All Grown Up! and is among the series' original characters.
She is a spoiled brat and the cousin of Tommy and Dil Pickles. In 2002, TV Guide declared Angelica Pickles 7th in their list of Top 50 Greatest Cartoon Characters of All Time. She is the archenemy of Tommy Pickles and the other Rugrats. Her middle name is 'Charlotte', meaning she is named after her mother. She claims to be 'the prettiest, most beautiful kid in the universe'. Angelica carries her favorite doll Cynthia (a parody of the popular Barbie franchise) around with her almost everywhere and fills her room with Cynthia merchandise.